ABSTRACT
Objective To investigate the relationship between Homocysteine (Hcy) and incipient diabetic nephropathy in type 2 diabetes mellitus (DM).Methods The plasma Hcy level was measured by high performance liquid chromatography with fluorescence detection in 67 patients with type 2 DM and 47 control persons,the plasma thrombomodulin(sTM),folate and vitamin B 12 were determined simultaneously.Results The plasma Hcy level was higher in type 2 DM patients than that in control subjects (15.27?6.04?mol/L vs 12.10?1.86?mol/L, P
ABSTRACT
Platelet aggregation, plasma factor Ⅷ-related antigen (Ⅷ R:Ag) and fibrinogen were measured in 23 newly diagnosed diabetic patients after two weeks on diet alone, and at the 2nd, 4th and 6th month during treatment with glipizide. 9 of the 23 patients had microangiopathy and the other 14 had not. On diet alone, the maximal platelet aggregation in diabetic subjects was increased significantly in response to various concentrations of adenosine diphos-phate or adrenaline as compared with those in normal controls (P